TissueTMDD

Introduction

This model is based on the PK-Sim model for large molecules in humans and is extended in Mobi with target binding to a target expressed in the interstitial space of an organ.
The target is degraded with a first-order rate constant \(k_{deg}\) and synthesized with a zero-order rate constant \(k_{syn}\) which is calculated as the product of the target concentration in the interstitial space and the \(k_{deg}\).
The drug-target complex is degraded with a first-order rate constant \(k_{int}\).
Various outputs can be selected in the plot options.
Disclaimer: no rights can be derived from this model or any of its output.

Simulation Settings

Presets

Import

Kdeg [/h]

Kd, [nM]

Koff, [/h]

Kint

Target Concentration, [nM]

Organ

Molecular Weight [kDa]

Dose, [mg/kg]

Dose Frequency

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